Quantitative MR diffusion mapping and cyclosporine-induced neurotoxicity

Coley, S. C., Porter, D. A., Calamante, F., Chong, W. K. and Connelly, A. (1999) Quantitative MR diffusion mapping and cyclosporine-induced neurotoxicity. American Journal of Neuroradiology, 20(8), pp. 1507-1510. (PMID:10512238)

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Publisher's URL: http://www.ajnr.org/content/20/8/1507

Abstract

Apparent diffusion coefficient maps of two patients with cyclosporine-induced neurotoxicity showed areas of increased diffusion that corresponded to the characteristic regions of signal change on routine T2-weighted sequences. The majority of lesions subsequently resolved without residual T2 or diffusion signal alteration. These findings suggest that, in our patients, the neurotoxic effects of cyclosporine resulted in a partially reversible extravasation of fluid into the cerebral interstitium and were not associated with acute ischemia.

Item Type:Articles
Additional Information:We thank the Wellcome Trust for financial support.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Porter, Professor David
Authors: Coley, S. C., Porter, D. A., Calamante, F., Chong, W. K., and Connelly, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:American Journal of Neuroradiology
Publisher:American Society of Neuroradiology
ISSN:0195-6108
ISSN (Online):1936-959X

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