Management of lipid abnormalities in patients with diabetes

Sillars, A. and Sattar, N. (2019) Management of lipid abnormalities in patients with diabetes. Current Cardiology Reports, 21(11), 147. (doi: 10.1007/s11886-019-1246-1) (PMID:31758270) (PMCID:PMC6874523)

Abstract

Purpose of Review: To describe lipid abnormalities in diabetes, when they occur and the evidence base for lipid management with established and new drugs to prevent diabetes complications. We also discuss how to manage statin intolerance. Recent Findings: Statins remain first-line therapy in patients with diabetes, though newer therapies to reduce LDL-C have emerged, including ezetimibe as an add-on therapy to statins, and injectable PCSK9 inhibitors, both of which are safe and effective in diabetes. Emerging evidence suggests a need to consider lipid-lowering therapies more often in younger patients with both type 1 and type 2 diabetes. Summary: Statins remain the cornerstone of lipid management in diabetes but other options are increasing. There is also now evidence for better managing apparent statin intolerance. Notably, younger patients lose the most life years from their diabetes, an observation that future guidelines need to consider.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Sillars, Dr Anne and Sattar, Professor Naveed
• Authors: Sillars, A., and Sattar, N.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Current Cardiology Reports
• Publisher: Springer
• ISSN: 1523-3782
• ISSN (Online): 1534-3170
• Published Online: 22 November 2019
• Copyright Holders: Copyright © The Authors 2019
• First Published: First published in Current Cardiology Reports 21(11):147
• Publisher Policy: Reproduced under a Creative Commons license