Frame, M.C. and Brunton, V.G. (2002) Advances in Rho-dependent actin regulation and oncogenic transformation. Current Opinion in Genetics and Development, 12, pp. 36-43. (doi: 10.1016/S0959-437X(01)00261-1)
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Abstract
Cellular movement is central to invasion. The Rho family of small GTPases co-ordinate the cytoskeletal and adhesion modelling within cells that is crucial for normal migratory responses. Consequently, Rho proteins, and their regulators and effectors, are targets for subversion during oncogenic transformation and tumour development. Recent findings have thrown light on how actin regulators may be linked to oncogenesis and the development of cancer.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Brunton, Dr Valerie and Frame, Prof Margaret |
| Authors: | Frame, M.C., and Brunton, V.G. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Current Opinion in Genetics and Development |
| ISSN: | 0959-437X |
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