Rumpel, H., Chong, Y., Porter, D. A. and Chan, L. L. (2013) Benign versus metastatic vertebral compression fractures: combined diffusion-weighted MRI and MR spectroscopy aids differentiation. European Radiology, 23(2), pp. 541-550. (doi: 10.1007/s00330-012-2620-1) (PMID:22903620)
Full text not currently available from Enlighten.
Abstract
Objectives: To determine the residual lipid fraction in fractured vertebrae by 1H MR spectroscopy (MRS) and its confounding effect on differentiating benign from metastatic compression fractures of the spine using apparent diffusion coefficient (ADC) obtained by diffusion-weighted read-out-segmented echo-planar imaging. Methods: Fifty-two patients presenting with back pain and/or vertebral compression fractures related to different degrees of acute trauma, osteoporosis or clinically known metastatic disease underwent imaging at 1.5 T using (a) single-voxel MRS for water and lipid compositions over the fractured vertebral marrow, and (b) DWI at b = 0 and 650 s/mm2 to compute the ADC values. Results: In 46 fractured vertebrae, the amount of lipid displaced was variable. In low-impact trauma, lipid was either displaced partially (ADC of 1.60 ± 0.20 × 10−3 mm2/s) or almost totally with a higher ADC (2.20 ± 0.27 × 10−3 mm2/s). In acute high-impact trauma, the lipid fraction was negligible, yet an intermediate ADC was observed. In tumour infiltration, ADC was also intermediate (1.22 ± 0.14 × 10−3 mm2/s) despite a negligible lipid fraction. The ROC curve yielded a diagnostic accuracy of 0.944. Conclusion: ADC-MRS analysis provides knowledge of the residual lipid fraction in fractured vertebrae that could aid in the differentiation between benign and metastatic vertebral fractures in low-impact trauma.
Item Type: | Articles |
---|---|
Additional Information: | This study was funded by SingHealth Grant Singapore. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Porter, Professor David |
Authors: | Rumpel, H., Chong, Y., Porter, D. A., and Chan, L. L. |
College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
Journal Name: | European Radiology |
Publisher: | Springer |
ISSN: | 0938-7994 |
ISSN (Online): | 1432-1084 |
Published Online: | 18 August 2012 |
University Staff: Request a correction | Enlighten Editors: Update this record