Effect of B-value in revealing postinfarct myocardial microstructural remodeling using MR diffusion tensor imaging

Wu, Y., Zou, C., Liu, W., Liao, W., Yang, W., Porter, D. A., Liu, X. and Wu, E. X. (2013) Effect of B-value in revealing postinfarct myocardial microstructural remodeling using MR diffusion tensor imaging. Magnetic Resonance Imaging, 31(6), pp. 847-856. (doi: 10.1016/j.mri.2013.02.010) (PMID:23602723)

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Abstract

Nonmonoexponential diffusion behavior has been previously reported to exist in some biological tissues, making quantification of diffusion tensor imaging (DTI) indices dependent on diffusion sensitivity of b-value. This study aims to investigate the effect of b-value in revealing postinfarct myocardial microstructural remodeling in ex vivo hearts. DTI scans were performed on heart samples 1, 3, 5, and 7 days after infarction induction as well as intact controls with b-values of 500 to 2500 s/mm2. DTI indices, including fractional anisotropy (FA), and mean and directional diffusivities, were measured in infarct, adjacent and remote regions with zero and each non-zero b-values respectively using conventional DTI analysis. Experimental results showed that these DTI indices decreased gradually with b-values in all regions and groups. Optimal b-values were found to vary with targeted DTI indices, and could strengthen DTI ability in revealing myocardium degradation with using conventional DTI approach. Specifically, FA showed the most sensitive detection of fiber integrity degradation at moderate b-values (≈ 1500 to 2000 s/mm2), and the greatest ability of mean and directional diffusivities in monitoring diffusivity alteration occurred at relatively small b-values (≤ 1500 s/mm2) during the necrotic and fibrotic phases. These findings may provide useful information for DTI protocol parameter optimization in assessing heart microstructures at other pathological or in vivo states in the future.

Item Type:Articles
Additional Information:The study was supported by National Natural Science Foundation of China (30900387), National Basic Research 973 Program of China (No. 2011CB707903), Hong Kong Research Grant Council (GRF HKU7826/10M), Introduction of Innovative RandD Team Program of Guangdong Province (LCHT and 201001S0104811217), and Basic Research Program of Shenzhen (JC201005270311A).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Porter, Professor David
Authors: Wu, Y., Zou, C., Liu, W., Liao, W., Yang, W., Porter, D. A., Liu, X., and Wu, E. X.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Magnetic Resonance Imaging
Publisher:Elsevier
ISSN:0730-725X
ISSN (Online):1873-5894
Published Online:18 April 2013

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