Expert statement on the ICU management of patients with thrombotic thrombocytopenic purpura

Azoulay, E. et al. (2019) Expert statement on the ICU management of patients with thrombotic thrombocytopenic purpura. Intensive Care Medicine, 45(11), pp. 1518-1539. (doi: 10.1007/s00134-019-05736-5) (PMID:31588978)

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199605.pdf - Accepted Version



Thrombotic thrombocytopenic purpura (TTP) is fatal in 90% of patients if left untreated and must be diagnosed early to optimize patient outcomes. However, the very low incidence of TTP is an obstacle to the development of evidence-based clinical practice recommendations, and the very wide variability in survival rates across centers may be partly ascribable to differences in management strategies due to insufficient guidance. We therefore developed an expert statement to provide trustworthy guidance about the management of critically ill patients with TTP. As strong evidence was difficult to find in the literature, consensus building among experts could not be reported for most of the items. This expert statement is timely given the recent advances in the treatment of TTP, such as the use of rituximab and of the recently licensed drug caplacizumab, whose benefits will be maximized if the other components of the management strategy follow a standardized pattern. Finally, unanswered questions are identified as topics of future research on TTP.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Puxty, Dr Kathryn
Authors: Azoulay, E., Bauer, P. R., Mariotte, E., Russell, L., Knoebl, P., Martin-Loeches, I., Pène, F., Puxty, K., Povoa, P., Barratt-Due, A., Garnacho-Montero, J., Wendon, J., Munshi, L., Benoit, D., von Bergwelt-Baildon, M., Maggiorini, M., Coppo, P., Cataland, S., Veyradier, A., and Van de Louw, A.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Intensive Care Medicine
ISSN (Online):1432-1238
Published Online:07 October 2019
Copyright Holders:Copyright © 2019 Springer-Verlag GmbH Germany
First Published:First published in Intensive Care Medicine 45(11): 1518-1539
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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