Kalla, R., Ventham, N.T., Kennedy, N.A., Quintana, J.F. , Nimmo, E.R., Buck, A.H. and Satsangi, J. (2015) MicroRNAs: new players in IBD. Gut, 64(3), pp. 504-513. (doi: 10.1136/gutjnl-2014-307891) (PMID:25475103) (PMCID:PMC4345829)
|
Text
199072.pdf - Published Version Available under License Creative Commons Attribution. 4MB |
Abstract
MicroRNAs (miRNAs) are small non-coding RNAs, 18–23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the pathogenesis of many common diseases, including IBDs. This review aims to outline the history, biogenesis and regulation of miRNAs. The role of miRNAs in the development and regulation of the innate and adaptive immune system is discussed, with a particular focus on mechanisms pertinent to IBD and the potential translational applications.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Quintana, Dr Juan |
| Authors: | Kalla, R., Ventham, N.T., Kennedy, N.A., Quintana, J.F., Nimmo, E.R., Buck, A.H., and Satsangi, J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Gut |
| Publisher: | BMJ Publishing Group |
| ISSN: | 0017-5749 |
| ISSN (Online): | 1468-3288 |
| Published Online: | 04 December 2014 |
| Copyright Holders: | Copyright © 2015 The Authors |
| First Published: | First published in Gut 64(3): 504-513 |
| Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric