Quintana, J. F. , Canavate Del Pino, R., Yamada, K., Zhang, N. and Field, M. C. (2018) Adaptation and therapeutic exploitation of the plasma membrane of African trypanosomes. Genes, 9(7), 368. (doi: 10.3390/genes9070368) (PMID:30037058) (PMCID:PMC6071061)
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Abstract
African trypanosomes are highly divergent from their metazoan hosts, and as part of adaptation to a parasitic life style have developed a unique endomembrane system. The key virulence mechanism of many pathogens is successful immune evasion, to enable survival within a host, a feature that requires both genetic events and membrane transport mechanisms in African trypanosomes. Intracellular trafficking not only plays a role in immune evasion, but also in homeostasis of intracellular and extracellular compartments and interactions with the environment. Significantly, historical and recent work has unraveled some of the connections between these processes and highlighted how immune evasion mechanisms that are associated with adaptations to membrane trafficking may have, paradoxically, provided specific sensitivity to drugs. Here, we explore these advances in understanding the membrane composition of the trypanosome plasma membrane and organelles and provide a perspective for how transport could be exploited for therapeutic purposes.
| Item Type: | Articles |
|---|---|
| Additional Information: | This research was funded by the Medical Research Council grant number [MR/N010558/1, MR/P009018/1] and the Wellcome Trust [204697/Z/16/Z] (all to M.C.F.). M.C.F. is a Wellcome Investigator. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Quintana, Dr Juan |
| Creator Roles: | |
| Authors: | Quintana, J. F., Canavate Del Pino, R., Yamada, K., Zhang, N., and Field, M. C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Genes |
| Publisher: | MDPI |
| ISSN: | 2073-4425 |
| ISSN (Online): | 2073-4425 |
| Published Online: | 20 July 2018 |
| Copyright Holders: | Copyright © 2018 The Authors |
| First Published: | First published in Genes 9(7): 368 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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