Adaptation and therapeutic exploitation of the plasma membrane of African trypanosomes

Quintana, J. F. , Canavate Del Pino, R., Yamada, K., Zhang, N. and Field, M. C. (2018) Adaptation and therapeutic exploitation of the plasma membrane of African trypanosomes. Genes, 9(7), 368. (doi: 10.3390/genes9070368) (PMID:30037058) (PMCID:PMC6071061)

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Abstract

African trypanosomes are highly divergent from their metazoan hosts, and as part of adaptation to a parasitic life style have developed a unique endomembrane system. The key virulence mechanism of many pathogens is successful immune evasion, to enable survival within a host, a feature that requires both genetic events and membrane transport mechanisms in African trypanosomes. Intracellular trafficking not only plays a role in immune evasion, but also in homeostasis of intracellular and extracellular compartments and interactions with the environment. Significantly, historical and recent work has unraveled some of the connections between these processes and highlighted how immune evasion mechanisms that are associated with adaptations to membrane trafficking may have, paradoxically, provided specific sensitivity to drugs. Here, we explore these advances in understanding the membrane composition of the trypanosome plasma membrane and organelles and provide a perspective for how transport could be exploited for therapeutic purposes.

Item Type:Articles
Additional Information:This research was funded by the Medical Research Council grant number [MR/N010558/1, MR/P009018/1] and the Wellcome Trust [204697/Z/16/Z] (all to M.C.F.). M.C.F. is a Wellcome Investigator.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Quintana, Dr Juan
Creator Roles:
Quintana, J. F.Conceptualization, Writing – original draft, Writing – review and editing
Authors: Quintana, J. F., Canavate Del Pino, R., Yamada, K., Zhang, N., and Field, M. C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Genes
Publisher:MDPI
ISSN:2073-4425
ISSN (Online):2073-4425
Published Online:20 July 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Genes 9(7): 368
Publisher Policy:Reproduced under a Creative Commons License

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