Cure of innate intestinal immune pathology by CD4+CD25+ regulatory T cells

Maloy, K. J. , Antonelli, L. R.V., Lefevre, M. and Powrie, F. (2005) Cure of innate intestinal immune pathology by CD4+CD25+ regulatory T cells. Immunology Letters, 97(2), pp. 189-192. (doi: 10.1016/j.imlet.2005.01.004) (PMID:15752557)

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CD4+CD25+ regulatory T (T(R)) cells are a naturally occurring population of T cells that suppress the development of a variety of pathological immune responses. However, as human inflammatory diseases are usually not diagnosed until after the onset of clinical symptoms, it is of great interest to determine whether CD4+CD25+ T(R) cells can reverse established pathology. To examine this question we have utilized a murine model of human inflammatory bowel disease (IBD), where pathology is triggered by infection of immune deficient RAG-/- mice with the pathogenic bacterium Helicobacter hepaticus. Here we demonstrate that adoptively transferred CD4+CD25+ T(R) cells can cure established intestinal inflammation that is mediated by innate immune activation in H. hepaticus-infected RAG-/- mice. CD4+CD25+ T(R) cell-mediated amelioration of innate intestinal pathology was accompanied by a reversal in systemic innate immune activation, but did not involve any detectable anti-bacterial effects, as bacterial colonization levels were unchanged. Cure of established pathology was not achieved using subpopulations of CD4+CD25- T cells, further emphasizing the enhanced regulatory activity of CD4+CD25+ T(R) cells.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Maloy, Professor Kevin
Authors: Maloy, K. J., Antonelli, L. R.V., Lefevre, M., and Powrie, F.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Immunology Letters
ISSN (Online):1879-0542
Published Online:02 February 2005

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