Cu2+ effects on beta‐amyloid oligomerisation monitored by fluorescence of intrinsic tyrosine

Rolinski, O. J., Alghamdi, A., Wellbrock, T., Birch, D. J.S. and Vyshemirsky, V. (2019) Cu2+ effects on beta‐amyloid oligomerisation monitored by fluorescence of intrinsic tyrosine. ChemPhysChem, 20(23), pp. 3181-3185. (doi: 10.1002/cphc.201900565) (PMID:31539190)

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Abstract

A non‐invasive intrinsic fluorescence sensing of the early stages of Alzheimer’s beta amyloid peptide aggregation in the presence of copper ions is reported. By using time‐resolved fluorescence techniques the formation of beta amyloid‐copper complexes and the accelerated peptide aggregation are demonstrated. The shifts in the emission spectral peaks indicate that the peptides exhibit different aggregation pathways than in the absence of copper.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Vyshemirsky, Dr Vladislav
Authors: Rolinski, O. J., Alghamdi, A., Wellbrock, T., Birch, D. J.S., and Vyshemirsky, V.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Statistics
Journal Name:ChemPhysChem
Publisher:Wiley
ISSN:1439-4235
ISSN (Online):1439-7641
Published Online:20 September 2019
Copyright Holders:Copyright © 2019 Wiley‐VCH Verlag GmbH and Co
First Published:First published in ChemPhysChem 20(23): 3181-3185
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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