Gene manipulation to enhance MIBG-targeted radionuclide therapy

Mairs, R. , Fullerton, N., Cosimo, E. and Boyd, M. (2005) Gene manipulation to enhance MIBG-targeted radionuclide therapy. Nuclear Medicine and Biology, 32(7), pp. 749-753. (doi: 10.1016/j.nucmedbio.2005.03.011)

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The goal of targeted radionuclide therapy is the deposition in malignant cells of sterilizing doses of radiation without damaging normal tissue. The radiopharmaccutical [I-131] meta-iodobenzylguanidine ([I-131]MIBG) is an effective single agent for the treatment of neuroblastoma. However, uptake of the drug in malignant sites is insufficient to cure disease. A growing body of experimental evidence indicates exciting possibilities for the integration of gene transfer with [I-131]MIBG-targeted radiotherapy.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Mairs, Professor Robert and Boyd, Dr Marie
Authors: Mairs, R., Fullerton, N., Cosimo, E., and Boyd, M.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Nuclear Medicine and Biology

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