Khandazhinskaya, A. L. et al. (2019) Investigation of 5’-norcarbocyclic nucleoside analogues as antiprotozoal and antibacterial agents. Molecules, 24(19), e3433. (doi: 10.3390/molecules24193433) (PMID:31546633)
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Abstract
Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both Mycobacterium tuberculosis and several parasitic strains. As a result, a small structure activity relationship study was designed to further probe their activity and potential. Their synthesis and the results of the subsequent biological activity are reported herein.
Item Type: | Articles |
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Additional Information: | Funding: This research was funded by Russian Foundation for Basic Research, grant № 18-29-08010. In addition, KJA was funded through a studentship from Taif University, Taif, Saudi Arabia. MJN was funded by a research fellowship from the government of Saudi Arabia (grant number S8306). |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Alzahrani, Khalid Jamaan and De Koning, Professor Harry and Natto, Dr Manal |
Creator Roles: | Alzahrani, K. J.Investigation Natto, M.Investigation De Koning, H. P.Methodology, Validation, Resources, Writing – review and editing, Supervision, Funding acquisition |
Authors: | Khandazhinskaya, A. L., Matyugina, E. S., Solyev, P. N., Wilkinson, M., Buckheit, K. W., Buckheit, R. W., Chernousova, L. N., Smirnova, T. G., Andreevskaya, S. N., Alzahrani, K. J., Natto, M. J., Kochetkov, S. N., De Koning, H. P., and Seley-Radtke, K. L. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Molecules |
Publisher: | MDPI |
ISSN: | 1420-3049 |
ISSN (Online): | 1420-3049 |
Published Online: | 21 September 2019 |
Copyright Holders: | Copyright © 2019 by the authors |
First Published: | First published in Molecules 24(19):e3433 |
Publisher Policy: | Reproduced under a Creative Commons license |
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