Multicentre validation of the CamGFR model for estimated glomerular filtration rate

Williams, E. H. et al. (2019) Multicentre validation of the CamGFR model for estimated glomerular filtration rate. JNCI Cancer Spectrum, 3(4), pkz068. (doi: 10.1093/jncics/pkz068) (PMID:31750418) (PMCID:PMC6846361)

Abstract

Important oncological management decisions rely on kidney function assessed by serum creatinine-based estimated glomerular filtration rate (eGFR). However, no large-scale multicentre comparison of methods to determine eGFR in patients with cancer are available. To compare the performance of formulas for eGFR based on routine clinical parameters and serum creatinine not calibrated with isotope dilution mass spectrometry (non-IDMS), we studied 3,620 patients with cancer and 166 without cancer who had their GFR measured with an exogenous nuclear tracer at one of seven clinical centres. The mean measured GFR was 86 ml/min. Accuracy of all models was centre-dependent, reflecting inter-centre variability of non-IDMS creatinine measurements. CamGFR was the most accurate model for eGFR (root-mean-squared-error (RMSE) 17.3 ml/min) followed by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) model (RMSE 18.2 ml/min).

• Item Type: Articles
• Additional Information: This work was supported by Cancer Research UK (EW, TJ: C42738/A24868); National Institute for Health Research Cambridge Biomedical Research Centre (HE); National Institute for Health Research UK Academic Clinical Fellowship (CMC); and National Intitute of Health USA Cancer Center support grant (TJ: 5P30CA045508-31).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Mark, Professor Patrick
• Authors: Williams, E. H., Connell, C. M., Weaver, J. M.J., Beh, I., Potts, H., Whitley, C. T., Bird, N., Al-Sayed, T., Monaghan, P., Fehr, M., Cathomas, R., Bertelli, G., Quinton, A., Lewis, P., Shamash, J., Wilson, P., Dooley, M., Poole, S., Mark, P. B., Bookman, M. A., Earl, H., Jodrell, D., Tavaré, S., Lynch, A. G., and Janowitz, T.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: JNCI Cancer Spectrum
• Publisher: Oxford University Press
• ISSN: 2515-5091
• ISSN (Online): 2515-5091
• Published Online: 19 September 2019
• Copyright Holders: Copyright © 2019 The Authors
• First Published: First published in JNCI Cancer Spectrum 3(4): pkz068
• Publisher Policy: Reproduced under a Creative Commons License