Robust and rapidly tunable light source for SRS/CARS microscopy with low-intensity noise

Linnenbank, H., Steinle, T., Mörz, F., Flöss, M., Cui, H. , Glidle, A. and Giessen, H. (2019) Robust and rapidly tunable light source for SRS/CARS microscopy with low-intensity noise. Advanced Photonics, 1(5), 055001. (doi: 10.1117/1.AP.1.5.055001)

Abstract

We present a fully automated laser system with low-intensity noise for coherent Raman scattering microscopy. The robust two-color system is pumped by a solid-state oscillator, which provides Stokes pulses fixed at 1043 nm. The tunable pump pulses of 750 to 950 nm are generated by a frequency-doubled fiber-feedback femtosecond optical parametric oscillator. The resulting pulse duration of 1.2 ps provides a viable compromise between optimal coherent Raman scattering signal and the necessary spectral resolution. Thus a spectral range of 1015 to 3695  cm  −  1 with spectral resolution of <13  cm  −  1 can be addressed.

• Item Type: Articles
• Additional Information: The authors gratefully acknowledge financial support by the ERC Advanced Grant (COMPLEXPLAS); DFG (Nos. SPP1391, SPP 1839, FOR730, and GI 269/11-1); the Bundesministerium für Bildung und Forschung (Nos. 13N9048, 13N10146, and PRINTOPTICS), the Carl Zeiss Foundation; the Baden-Württemberg Stiftung (Spitzenforschung II); the University of Stuttgart (open access fund); the EPSRC (No. EP/P001114/1); and the SRPe PRER and PECRE Award 2017/18.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Glidle, Dr Andrew and Cui, Dr Han
• Authors: Linnenbank, H., Steinle, T., Mörz, F., Flöss, M., Cui, H., Glidle, A., and Giessen, H.
• College/School: College of Science and Engineering > School of Engineering > Biomedical Engineering
• Journal Name: Advanced Photonics
• Publisher: SPIE and Chinese Laser Press
• ISSN: 2577-5421
• ISSN (Online): 2577-5421
• Published Online: 24 September 2019
• Copyright Holders: Copyright © 2019 The Authors
• First Published: First published in Advanced Photonics 1(5): 055001
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
173192		Engineering growth factor microenvironments- a new therapeutic paradigm for regenerative medicine	Manuel Salmeron-Sanchez	Engineering and Physical Sciences Research Council (EPSRC)	EP/P001114/1	ENG - Biomedical Engineering