Kafi, M. A., Paul, A., Vilouras, A. and Dahiya, R. (2018) Chitosan-Graphene Oxide Based Ultra-Thin Conformable Sensing Patch for Cell-Health Monitoring. In: 2018 IEEE Sensors, New Delhi, India, 28-31 Oct 2018, ISBN 9781538647073 (doi: 10.1109/ICSENS.2018.8589782)
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Abstract
The work presents a Chitosan-Graphene Oxide (Chi-GO) based ultra-thin sensors patch having arrays of gold (Au) based micro-gap (\pmb60μ m) electrode. The cross-linked GO is shown to improve the stability of chitosan substrate in aqueous medium. With human dermal fibroblast (HDF) cell immobilized Chi-GO surface, the sensor patch has been evaluated for label free monitoring. The cyclic voltammetry (CV) of cell immobilized chi-GO surface showed quasi-reversible nature with characteristic cathodic peak at + 300mV and anodic peak - 300mV. Both peaks are stable and repeatable up to 50-scan cycle without any potential shift. The device shows steady state peak enhancement (1.923-11.195nA) with the growth period (O-96h). The redox peak enhancement correlates with the proliferation rates of cell over time, indicating that it could be employed to investigate cyto-physiologic state against any endo and exogenous stimulation. The new compatibility of cross-linked chitosan with microfabrication steps and the ability of presented sensor patch to monitor cell-health will benefit a range of in vivo applications.
Item Type: | Conference Proceedings |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Vilouras, Anastasios and Kafi, Md Abdul and Dahiya, Professor Ravinder and Paul, Dr Ambarish |
Authors: | Kafi, M. A., Paul, A., Vilouras, A., and Dahiya, R. |
College/School: | College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering |
ISSN: | 2168-9229 |
ISBN: | 9781538647073 |
Published Online: | 27 December 2018 |
Copyright Holders: | Copyright © 2018 IEEE |
First Published: | First published in 2018 IEEE Sensors |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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