Ofon, E., Noyes, H., Ebo’o Eyanga, V., Njiokou, F., Koffi, M., Fogue, P., Hertz-Fowler, C., MacLeod, A. , Matovu, E. and Simo, G. (2019) Association between IL1 gene polymorphism and human African trypanosomiasis in populations of sleeping sickness foci of southern Cameroon. PLoS Neglected Tropical Diseases, 13(3), e0007283. (doi: 10.1371/journal.pntd.0007283) (PMID:30908482) (PMCID:PMC6448947)
|
Text
195730.pdf - Published Version Available under License Creative Commons Attribution. 778kB |
Abstract
Background: Human African Trypanosomiasis (HAT) is a neglected tropical disease caused by infections due to Trypanosoma brucei subspecies. In addition to the well-established environmental and behavioural risks of becoming infected, there is evidence for a genetic component to the response to trypanosome infection. We undertook a candidate gene case-control study to investigate genetic associations further. Methodology: We genotyped one polymorphism in each of seven genes (IL1A, IL1RN, IL4RN, IL6, HP, HPR, and HLA-G) in 73 cases and 250 controls collected from 19 ethno-linguistic subgroups stratified into three major ethno-linguistic groups, 2 pooled ethno-linguistic groups and 11 ethno-linguistic subgroups from three Cameroonian HAT foci. The seven polymorphic loci tested consisted of three SNPs, three variable numbers of tandem repeat (VNTR) and one INDEL. Results: We found that the genotype (TT) and minor allele (T) of IL1A gene as well as the genotype 1A3A of IL1RN were associated with an increased risk of getting Trypanosoma brucei gambiense and develop HAT when all data were analysed together and also when stratified by the three major ethno-linguistic groups, 2 pooled ethno-linguistic subgroups and 11 ethno-linguistic subgroups. Conclusion: This study revealed that one SNP rs1800794 of IL1A and one VNTR rs2234663 of IL1RN were associated with the increased risk to be infected by Trypanosoma brucei gambiense and develop sleeping sickness in southern Cameroon. The minor allele T and the genotype TT of SNP rs1800794 in IL1A as well as the genotype 1A3A of IL1RN rs2234663 VNTR seem to increase the risk of getting Trypanosoma brucei gambiense infections and develop sleeping sickness in southern Cameroon.
Item Type: | Articles |
---|---|
Additional Information: | The authors are grateful to the University of Dschang as well as the Wellcome Trust for funding this work (099310/Z/12/Z) as part of its support for the H3Africa initiative (http://h3africa.org/). |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | MacLeod, Professor Annette and Matovu, Dr Enock |
Creator Roles: | MacLeod, A.Funding acquisition, Writing – review and editing Matovu, E.Conceptualization, Funding acquisition, Project administration |
Authors: | Ofon, E., Noyes, H., Ebo’o Eyanga, V., Njiokou, F., Koffi, M., Fogue, P., Hertz-Fowler, C., MacLeod, A., Matovu, E., and Simo, G. |
College/School: | College of Medical Veterinary and Life Sciences > School of Life Sciences College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
Journal Name: | PLoS Neglected Tropical Diseases |
Publisher: | Public Library of Science |
ISSN: | 1935-2727 |
ISSN (Online): | 1935-2735 |
Copyright Holders: | Copyright © 2019 Ofon et al. |
First Published: | First published in PLoS Neglected Tropical Diseases 13(3): e0007283 |
Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record