T-tubule remodelling and ryanodine receptor organization modulate sodium-calcium exchange

Sipido, K. R., Acsai, K., Antoons, G., Bito, V. and MacQuaide, N. (2012) T-tubule remodelling and ryanodine receptor organization modulate sodium-calcium exchange. In: Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications. Series: Advances in Experimental Medicine and Biology (961). Springer: Boston, MA, pp. 375-383. ISBN 978-1-4614-4755-9 (doi: 10.1007/978-1-4614-4756-6_32)

Abstract

The Na+/Ca2+ exchanger (NCX) is a key regulator of intracellular Ca2+ in cardiac myocytes, predominantly contributing to Ca2+ removal during the diastolic relaxation process but also modulating excitation-contraction coupling. NCX is preferentially located in the T-tubules and can be close to or within the dyad, where L-type Ca2+ channels face ryanodine receptors (RyRs), the Ca2+ release channels of the sarcoplasmic reticulum. However, especially in larger animals, not all RyRs are in dyads or adjacent to T-tubules, and a substantial fraction of Ca2+ release from the sarcoplasmic reticulum thus occurs at distance from NCX. This chapter deals with the functional consequences of NCX location and how NCX can modulate diastolic and systolic Ca2+ events. The loss of T-tubules and the effects on RyR function and NCX modulation are explored, as well as quantitative measurement of local Ca2+ gradients at the level of the dyadic space.

• Item Type: Book Sections
• Status: Published
• Glasgow Author(s) Enlighten ID: MacQuaide, Dr Niall
• Authors: Sipido, K. R., Acsai, K., Antoons, G., Bito, V., and MacQuaide, N.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Advances in Experimental Medicine and Biology
• Publisher: Springer
• ISBN: 978-1-4614-4755-9
• Published Online: 25 October 2012