PET-CT as a predictor of outcome in resectable colorectal liver metastases

Jones, C., Badger, S. A., Stevenson, M., Diamond, T., McKie, L. D., Taylor, M. A., Wilson, R. H. and Lynch, T. B. (2014) PET-CT as a predictor of outcome in resectable colorectal liver metastases. European Journal of Gastroenterology and Hepatology, 26(4), pp. 466-472. (doi: 10.1097/MEG.0000000000000036) (PMID:24445726)

Abstract

Introduction: PET-computed tomography (PET-CT) is a useful staging imaging modality in colorectal liver metastases (CRLM). This study aimed to determine whether PET-CT parameters, standardized uptake value (SUV) and reconstructed tumour volume (RTV), are predictors of prognosis and survival. Methods: A study of all resectable CRLM patients in the regional HPB unit from 2007–2009 was performed. Preoperative PET-CT scans were retrospectively reviewed; SUV, diameter and RTV for each lesion was recorded. Correlation analysis was performed with other pathological and biochemical parameters, by Pearson’s correlation analysis. Survival analysis was performed using Cox regression hazard model. A P value of less than 0.05 was considered statistically significant. Results: A total of 79 patients were included. SUV moderately correlated with tumour diameter, both PET-CT (r= 0.4927; P< 0.0001) and histology (r= 0.4513; P= 0.0003); RTV (r= 0.4489; P < 0.001), preoperative carcinoembryonic antigen (CEA) (r = 0.4977; P = 0.0001), and postoperative CEA (r = 0.3727; P = 0.004). Multivariate analysis found that an independent predictor of SUVmax

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Wilson, Professor Richard
• Authors: Jones, C., Badger, S. A., Stevenson, M., Diamond, T., McKie, L. D., Taylor, M. A., Wilson, R. H., and Lynch, T. B.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: European Journal of Gastroenterology and Hepatology
• Publisher: Lippincott, Williams & Wilkins
• ISSN: 0954-691X
• ISSN (Online): 1473-5687