Graham, D. M., Coyle, V. M., Kennedy, R. D. and Wilson, R. H. (2016) Molecular subtypes and personalized therapy in metastatic colorectal cancer. Current Colorectal Cancer Reports, 12(3), pp. 141-150. (doi: 10.1007/s11888-016-0312-y) (PMID:27340376) (PMCID:PMC4879165)
|
Text
195554.pdf - Published Version Available under License Creative Commons Attribution. 602kB |
Abstract
Development of colorectal cancer occurs via a number of key pathways, with the clinicopathological features of specific subgroups being driven by underlying molecular changes. Mutations in key genes within the network of signalling pathways have been identified; however, therapeutic strategies to target these aberrations remain limited. As understanding of the biology of colorectal cancer has improved, this has led to a move toward broader genomic testing, collaborative research and innovative, adaptive clinical trial design. Recent developments in therapy include the routine adoption of wider mutational spectrum testing prior to use of targeted therapies and the first promise of effective immunotherapy for colorectal cancer patients. This review details current biomarkers in colorectal cancer for molecular stratification and for treatment allocation purposes, including open and planned precision medicine trials. Advances in our understanding, therapeutic strategy and technology will also be outlined.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Wilson, Professor Richard |
Authors: | Graham, D. M., Coyle, V. M., Kennedy, R. D., and Wilson, R. H. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Current Colorectal Cancer Reports |
Publisher: | Springer |
ISSN: | 1556-3790 |
ISSN (Online): | 1556-3804 |
Published Online: | 18 April 2016 |
Copyright Holders: | Copyright © 2016 The Authors |
First Published: | First published in Current Colorectal Cancer Reports 12(3):141-150 |
Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record