Molecular subtypes and personalized therapy in metastatic colorectal cancer

Graham, D. M., Coyle, V. M., Kennedy, R. D. and Wilson, R. H. (2016) Molecular subtypes and personalized therapy in metastatic colorectal cancer. Current Colorectal Cancer Reports, 12(3), pp. 141-150. (doi: 10.1007/s11888-016-0312-y) (PMID:27340376) (PMCID:PMC4879165)

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Abstract

Development of colorectal cancer occurs via a number of key pathways, with the clinicopathological features of specific subgroups being driven by underlying molecular changes. Mutations in key genes within the network of signalling pathways have been identified; however, therapeutic strategies to target these aberrations remain limited. As understanding of the biology of colorectal cancer has improved, this has led to a move toward broader genomic testing, collaborative research and innovative, adaptive clinical trial design. Recent developments in therapy include the routine adoption of wider mutational spectrum testing prior to use of targeted therapies and the first promise of effective immunotherapy for colorectal cancer patients. This review details current biomarkers in colorectal cancer for molecular stratification and for treatment allocation purposes, including open and planned precision medicine trials. Advances in our understanding, therapeutic strategy and technology will also be outlined.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Wilson, Professor Richard
Authors: Graham, D. M., Coyle, V. M., Kennedy, R. D., and Wilson, R. H.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Current Colorectal Cancer Reports
Publisher:Springer
ISSN:1556-3790
ISSN (Online):1556-3804
Published Online:18 April 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Current Colorectal Cancer Reports 12(3):141-150
Publisher Policy:Reproduced under a Creative Commons License

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