Gill, J. and Malkova, D. (2006) Effects of exercise on postprandial lipoprotein metabolism. Future Lipidology, 1, pp. 743-755. (doi: 10.2217/17460875.1.6.743)
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Abstract
A novel carrier system to deliver large exogenous molecules into the cytosol has advantages for efficient delivery compared with traditional transfection techniques. We previously prepared a fusogenic liposome (FL) system by fusing phospholipid-based conventional liposomes with ultraviolet inactivated Sendai virus, which possess membrane fusion activity derived from the Sendai virus accessory protein. The FLs deliver their contents rapidly and directly into the cytoplasm rather than by endocytosis via membrane fusion without cytotoxicity. This FL-mediated cytoplasmic delivery technique is a powerful tool with the potential for wide use in the field of gene regulation and for the development of gene therapy. This review focuses on the suitability of FLs as a versatile and effective gene delivery system.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Malkova, Dr Dalia and Gill, Professor Jason |
| Authors: | Gill, J., and Malkova, D. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities |
| Journal Name: | Future Lipidology |
| Publisher: | Future Medicine Ltd. |
| ISSN: | 1746-0875 |
| ISSN (Online): | 2641-5321 |
| Published Online: | 18 January 2007 |
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