Direct relationship between virus load and systemic immune activation in HIV-2 infection

Leligdowicz, A., Feldmann, J., Jaye, A., Cotten, M. , Dong, T., McMichael, A., Whittle, H. and Rowland-Jones, S. (2010) Direct relationship between virus load and systemic immune activation in HIV-2 infection. Journal of Infectious Diseases, 201(1), pp. 114-122. (doi: 10.1086/648733) (PMID:19938978)

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Abstract

Immune activation is a hallmark of disease progression in human immunodeficiency virus (HIV) type 1 (HIV-1) and HIV type 2 (HIV-2) infection. However, the relationship between viremia and systemic immune activation is unclear. We assessed the relationship between HIV-2 plasma virus load and immune system activation in a cross-sectional study in a community cohort of HIV-1-positive, HIV-2-positive, and HIV-negative patients, in which many HIV-2-positive patients had nonprogressing infection. HLA-DR and CD38 expression on CD4+ and CD8+ T cells was measured, as were plasma β2-microglobulin levels. These markers were related to clinical (virus load and CD4+ cell count) and immunological (HIV-2-specific interferon γ secretion) correlates of delayed disease progression. A consistent positive correlation was identified between the level of HIV-2 viremia and immune activation. We propose that increasing virus load may contribute to systemic immune activation in HIV-2 infection.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cotten, Professor Matthew
Authors: Leligdowicz, A., Feldmann, J., Jaye, A., Cotten, M., Dong, T., McMichael, A., Whittle, H., and Rowland-Jones, S.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:Journal of Infectious Diseases
Publisher:Infectious Diseases Society of America
ISSN:0022-1899
ISSN (Online):1537-6613

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