Freel, E. M. and Connell, J. M. C. (2005) Diagnosis of adenomatous primary aldosteronism in a patient with severe hypertension. Nature Clinical Practice Endocrinology and Metabolism, 1(2), pp. 111-115. (doi: 10.1038/ncpendmet0047)
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Publisher's URL: http://dx.doi.org/10.1038/ncpendmet0047
Abstract
<b>Background</b> A 27-year-old woman presented to her primary-care physician with severe hypertension after complaining of fatigue over the preceding months. She was otherwise asymptomatic. She was referred to a hypertension clinic and was found to be hypokalemic. She was immediately commenced on amlodipine, with atenolol added 2 weeks later. After 4 weeks of this drug therapy, her hypertension persisted and investigations to exclude secondary causes of hypertension were performed.<p></p> <b>Investigations</b> Aldosterone and renin levels were measured under controlled conditions and the results expressed as an aldosterone-to-renin ratio. CT of the adrenal glands was also performed.<p></p> <b>Diagnosis</b> Adenomatous primary aldosteronism (Conn's syndrome).<p></p> <b>Management</b> The patient was initially treated with spironolactone before undergoing a laparoscopic left adrenalectomy.<p></p>
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Connell, Professor John and Freel, Dr Marie |
| Authors: | Freel, E. M., and Connell, J. M. C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Nature Clinical Practice Endocrinology and Metabolism |
| Publisher: | Nature Publishing Group |
| ISSN: | 1745-8366 |
| ISSN (Online): | 1745-8374 |
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