The Malaria Cell Atlas: single parasite transcriptomes across the complete Plasmodium life cycle

Howick, V. M. et al. (2019) The Malaria Cell Atlas: single parasite transcriptomes across the complete Plasmodium life cycle. Science, 365(6455), eaaw2619. (doi: 10.1126/science.aaw2619) (PMID:31439762) (PMCID:PMC7056351)

Abstract

Malaria parasites adopt a remarkable variety of morphological life stages as they transition through multiple mammalian host and mosquito vector environments. We profiled the single-cell transcriptomes of thousands of individual parasites, deriving the first high-resolution transcriptional atlas of the entire life cycle. We then used our atlas to precisely define developmental stages of single cells from three different human malaria parasite species, including parasites isolated directly from infected individuals. The Malaria Cell Atlas provides both a comprehensive view of gene usage in a eukaryotic parasite and an open-access reference dataset for the study of malaria parasites.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Howick, Dr Virginia and Herren, Dr Jeremy
• Authors: Howick, V. M., Russell, A. J.C., Andrews, T., Heaton, H., Reid, A. J., Natarajan, K., Butungi, H., Metcalf, T., Verzier, L. H., Rayner, J. C., Berriman, M., Herren, J. K., Billker, O., Hemberg, M., Talman, A. M., and Lawniczak, M. K.N.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity; College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Science
• Publisher: American Association for the Advancement of Science
• ISSN: 0036-8075
• ISSN (Online): 1095-9203
• Copyright Holders: Copyright © 2019 The Authors
• First Published: First published in Science 365(6455): eaaw2619
• Publisher Policy: Reproduced in accordance with the publisher copyright policy