A criterion-based approach to systematic and transparent comparative effectiveness: a case study in psoriatic arthritis

Tremblay, G., Westley, T., Forsythe, A., Pelletier, C. and Briggs, A. (2019) A criterion-based approach to systematic and transparent comparative effectiveness: a case study in psoriatic arthritis. Journal of Comparative Effectiveness Research, 8(15), pp. 1265-1298. (doi: 10.2217/cer-2019-0064) (PMID:31774340)

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Abstract

Aim: Indirect treatment comparisons are used when no direct comparison is available. Comparison networks should satisfy the transitivity assumption, that is, equal likelihood of treatment assignment for a given patient based on comparability of studies. Materials and methods: Seven criteria were evaluated across 18 randomized controlled trials in psoriatic arthritis: inclusion/exclusion criteria, clinical trial design and follow-up, patient-level baseline characteristics, disease severity, prior therapies, concomitant and extended-trial treatment and placebo response differences. Results: Across studies, placebo was a common comparator, and key efficacy end points were reported. Collectively, several potential sources of insufficient transitivity were identified, most often related to trial design and population differences. Conclusion: Potential challenges in satisfying transitivity occur frequently and should be evaluated thoroughly.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Briggs, Professor Andrew
Authors: Tremblay, G., Westley, T., Forsythe, A., Pelletier, C., and Briggs, A.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Health Economics and Health Technology Assessment
Journal Name:Journal of Comparative Effectiveness Research
Publisher:Future Medicine
ISSN:2042-6305
ISSN (Online):2042-6313
Published Online:05 September 2019
Copyright Holders:Copyright © 2019 Gabriel Tremblay
First Published:First published in Journal of Comparative Effectiveness Research 8(15): 1265-1298
Publisher Policy:Reproduced under a Creative Commons license

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