Rodgers, J. , Steiner, I. and Kennedy, P. G.E. (2019) Generation of neuroinflammation in human African trypanosomiasis. Neurology: Neuroimmunology and Neuroinflammation, 6(6), e610. (doi: 10.1212/NXI.0000000000000610) (PMID:31467039) (PMCID:PMC6745723)
|
Text
194759.pdf - Published Version Available under License Creative Commons Attribution Non-commercial No Derivatives. 401kB |
Abstract
Human African trypanosomiasis (HAT) is caused by infection due to protozoan parasites of the Trypanosoma genus and is a major fatal disease throughout sub-Saharan Africa. After an early hemolymphatic stage in which the peripheral tissues are infected, the parasites enter the CNS causing a constellation of neurologic features. Although the CNS stage of HAT has been recognized for over a century, the mechanisms generating the neuroinflammatory response are complex and not well understood. Therefore a better understanding of the mechanisms utilized by the parasites to gain access to the CNS compartment is critical to explaining the generation of neuroinflammation. Contrast-enhanced MRI in a murine model of HAT has shown an early and progressive deterioration of blood-CNS barrier function after trypanosome infection that can be reversed following curative treatment. However, further studies are required to clarify the molecules involved in this process. Another important determinant of brain inflammation is the delicate balance of proinflammatory and counterinflammatory mediators. In mouse models of HAT, proinflammatory mediators such as tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and CXCL10 have been shown to be crucial to parasite CNS invasion while administration of interleukin (IL)-10, a counter inflammatory molecule, reduces the CNS parasite burden as well as the severity of the neuroinflammatory response and the clinical symptoms associated with the infection. This review focuses on information, gained from both infected human samples and animal models of HAT, with an emphasis on parasite CNS invasion and the development of neuroinflammation.
Item Type: | Articles |
---|---|
Additional Information: | Funded by University of Glasgow. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Kennedy, Professor Peter and Rodgers, Dr Jean |
Authors: | Rodgers, J., Steiner, I., and Kennedy, P. G.E. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
Journal Name: | Neurology: Neuroimmunology and Neuroinflammation |
Publisher: | Wolters Kluwer Health/LWW |
ISSN: | 2332-7812 |
ISSN (Online): | 2332-7812 |
Published Online: | 29 August 2019 |
Copyright Holders: | Copyright © 2019 The Authors |
First Published: | First published in Neurology: Neuroimmunology and Neuroinflammation 6(6):e610 |
Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record