Wind-up in lamina I spinoparabrachial neurons

Hachisuka, J. , Omori, Y., Chiang, M. C., Gold, M. S., Koerber, H. R. and Ross, S. E. (2018) Wind-up in lamina I spinoparabrachial neurons. Pain, 159(8), pp. 1484-1493. (doi:10.1097/j.pain.0000000000001229) (PMID:29578943) (PMCID:PMC6053328)

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Abstract

Wind-up is a frequency-dependent increase in the response of spinal cord neurons, which is believed to underlie temporal summation of nociceptive input. However, whether spinoparabrachial neurons, which likely contribute to the affective component of pain, undergo wind-up was unknown. Here, we addressed this question and investigated the underlying neural circuit. We show that one-fifth of lamina I spinoparabrachial neurons undergo wind-up, and provide evidence that wind-up in these cells is mediated in part by a network of spinal excitatory interneurons that show reverberating activity. These findings provide insight into a polysynaptic circuit of sensory augmentation that may contribute to the wind-up of pain’s unpleasantness.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hachisuka, Dr Junichi
Authors: Hachisuka, J., Omori, Y., Chiang, M. C., Gold, M. S., Koerber, H. R., and Ross, S. E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Pain
Publisher:Lippincott, Williams & Wilkins
ISSN:0304-3959
ISSN (Online):1872-6623
Published Online:23 March 2018

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