Meriç, P., Buduneli, N., Kanmaz, B., Gürlek, Ö., Çömlekoğlu, E., Calvert, G., Lappin, D. F. and Nile, C. (2019) Cholinergic signalling mechanisms and early implant healing phases in healthy versus generalized aggressive periodontitis patients: A prospective, case–control study. Journal of Clinical Periodontology, 46(11), pp. 1155-1163. (doi: 10.1111/jcpe.13185) (PMID:31444906)
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Abstract
Aims: Periodontal diseases negatively affect implant osseointegration. Perturbations in non‐neuronal cholinergic signaling mechanisms are associated with periodontitis; however, their role in generalized aggressive periodontitis (GAgP) is unknown. The aim of this prospective case‐control study was to determine the relationship between non‐neuronal cholinergic signaling mechanisms, Secreted Ly‐6/uPAR‐related protein‐1 (SLURP‐1), Interleukin‐17 (IL‐17) family cytokines and healing of dental implants in health and GAgP. Materials and Methods: Thirteen GAgP patients and seven periodontally healthy individuals (PH) were recruited. Peri‐implant crevicular fluid (PICF) was obtained at baseline and 1‐month post‐placement. Acetylcholine (ACh) levels and cholinesterase activity were determined biochemically. SLURP‐1, IL‐17A and IL‐17E levels were determined by ELISA. Marginal bone loss (MBL) at 1‐ and 6‐month(s) post‐placement was determined radiographically. Results: The concentration of ACh, cholinesterase activity and IL‐17A levels were elevated in PICF of patients with GAgP compared to PH individuals at baseline and 1‐month post‐placement. The concentration of ACh and cholinesterase activity levels in PICF correlated with levels of IL‐17A and MBL around implants 1‐month post‐placement in patients with GAgP. Conclusions: Non‐neuronal cholinergic mechanisms may play a role in the aetiopathogenesis of GAgP and may directly or indirectly, through modulation of IL‐17A, influence early implant osseointegration and potential long‐term implant survival.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Calvert, Mr Gareth and Lappin, Dr David and Nile, Dr Christopher |
| Authors: | Meriç, P., Buduneli, N., Kanmaz, B., Gürlek, Ö., Çömlekoğlu, E., Calvert, G., Lappin, D. F., and Nile, C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School |
| Journal Name: | Journal of Clinical Periodontology |
| Publisher: | Wiley |
| ISSN: | 0303-6979 |
| ISSN (Online): | 1600-051X |
| Published Online: | 24 August 2019 |
| Copyright Holders: | Copyright © 2019 John Wiley and Sons |
| First Published: | First published in Journal of Clinical Periodontology 46(11):1155-1163 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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