Druce, K. L. and Basu, N. (2019) Predictors of fatigue in rheumatoid arthritis. Rheumatology, 58(S5), v29-v34. (doi: 10.1093/rheumatology/kez346) (PMID:31435677) (PMCID:PMC6827266)
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Abstract
People with RA commonly experience fatigue. Fatigue is a key contributor to increased clinical care costs, primary care consultations and employment loss. Despite this, our understanding of the prognostic of factors of poor fatigue outcomes is lacking and fatigue is poorly managed. Examining longitudinal predictors of fatigue can identify both individuals ‘at risk’ of poor prognosis, and candidate mechanisms that are worthy of greater inspection. This review discusses the factors most commonly investigated as being implicated in the prognosis of RA fatigue. The available data appears to implicate generic factors such as pain, mental health, disability and sleep as consistent predictors of fatigue outcome, while the role of disease activity and inflammation seems less clear. However, the existing data are not without methodological limitations and there have been no specific studies primarily designed to investigate the inflammatory biomarkers of fatigue. Future studies are required to more comprehensively and robustly determine the mechanisms of fatigue.
| Item Type: | Articles |
|---|---|
| Additional Information: | Funding: The work in this manuscript was supported by the Centre for Epidemiology Versus Arthritis (formerly Arthritis Research UK) Centre Grant: 21755. This paper forms part of the supplement entitled Fatigue. This supplement was supported by Gilead. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Basu, Professor Neil |
| Authors: | Druce, K. L., and Basu, N. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Research Centre: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology |
| Journal Name: | Rheumatology |
| Publisher: | Oxford University Press |
| ISSN: | 1462-0324 |
| ISSN (Online): | 1462-0332 |
| Published Online: | 21 August 2019 |
| Copyright Holders: | Copyright © 2019 The Authors |
| First Published: | First published in Rheumatology 58:v29-v34 |
| Publisher Policy: | Reproduced under a Creative Commons license |
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