Barrier dysfunction in the nasal allergy

Fukuoka, A. and Yoshimoto, T. (2018) Barrier dysfunction in the nasal allergy. Allergology International, 67(1251), pp. 18-23. (doi: 10.1016/j.alit.2017.10.006) (PMID:29150353))

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Epithelial cells form the first physiological barrier against invasion by pathogens and the infiltration of allergens. Tight junctions (TJ), a cell–cell junctional complex located on the apical side of epithelial cells, have a critical role in the maintenance of epithelial barrier function. Impaired TJ structures are observed in patients with asthma, atopic dermatitis and nasal allergy; therefore, the dysfunction of epithelial barriers might be involved in the initiation or progression of allergic diseases. Protease-containing allergens and environmental pollutants enhance paracellular transport in epithelial cells through disruption of epithelial barrier function. This suggests that the disruption of TJ leads to the promotion of allergen delivery into the subepithelia, resulting in the progression of allergic diseases. Thus, protection of the epithelial barrier function might prevent or inhibit the development or exacerbation of allergic diseases. Recently, we reported that diesel exhaust particles (DEP), the main component of particulate patter 2.5, exacerbated allergic rhinitis (AR) in a mouse model through TJ disruption. In addition, we revealed that the oxidative stress-mediated pathway is involved in the effects caused by DEP and that nasal treatment with a reactive oxygen species (ROS) scavenger suppressed DEP-induced TJ disruption and exacerbation of AR. In this review, we focus on the relationship between TJ disruption and allergic disease. Furthermore, we discuss our recent findings regarding TJ disruption and the exacerbation of AR.

Item Type:Articles
Additional Information:This work was supported by a Grant-in-Aid for ScientificResearch B (15K19139) from the Japan Society for the Promotion ofScience.
Glasgow Author(s) Enlighten ID:Suzuki, Dr Ayumi
Authors: Fukuoka, A., and Yoshimoto, T.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Allergology International
ISSN (Online):1440-1592
Published Online:14 November 2017
Copyright Holders:Copyright © 2017 Japanese Society of Allergology
First Published:First published in Allergology International 67:18-23
Publisher Policy:Reproduced under a Creative Commons License

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