Reshaping cAMP nanodomains through targeted disruption of compartmentalised phosphodiesterase signalosomes

Blair, C. M. and Baillie, G. S. (2019) Reshaping cAMP nanodomains through targeted disruption of compartmentalised phosphodiesterase signalosomes. Biochemical Society Transactions, 47(5), pp. 1405-1414. (doi: 10.1042/BST20190252) (PMID:31506329)

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Spatio-temporal regulation of localised cAMP nanodomains is highly dependent upon the compartmentalised activity of phosphodiesterase (PDE) cyclic nucleotide degrading enzymes. Strategically positioned PDE–protein complexes are pivotal to the homeostatic control of cAMP-effector protein activity that in turn orchestrate a wide range of cellular signalling cascades in a variety of cells and tissue types. Unsurprisingly, dysregulated PDE activity is central to the pathophysiology of many diseases warranting the need for effective therapies that target PDEs selectively. This short review focuses on the importance of activating compartmentalised cAMP signalling by displacing the PDE component of signalling complexes using cell-permeable peptide disrupters

Item Type:Articles
Glasgow Author(s) Enlighten ID:Blair, Dr Connor and Baillie, Professor George
Authors: Blair, C. M., and Baillie, G. S.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Biochemical Society Transactions
Publisher:Portland Press
ISSN (Online):1470-8752
Published Online:10 September 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Biochemical Society Transactions 47(5):1405-1414
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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