Feng, L., Gao, H. , Griffith, B. E., Niderer, S. A. and Luo, X. (2019) Analysis of a coupled fluid-structure interaction model of the left atrium and mitral valve. International Journal for Numerical Methods in Biomedical Engineering, 35(11), e3254. (doi: 10.1002/cnm.3254) (PMID:31454470)
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Abstract
We present a coupled left atrium ‐ mitral valve model based on computed tomography scans with fibre‐reinforced hyperelastic materials. Fluid‐structure interaction is realised by using an immersed boundary‐finite element framework. Effects of pathological conditions, e.g. mitral valve regurgitation and atrial fibrillation, and geometric and structural variations, namely uniform vs non‐uniform atrial wall thickness and rule‐based vs atlas‐based fibre architectures, on the system are investigated. We show that in the case of atrial fibrillation, pulmonary venous flow reversal at late diastole disappears and the filling waves at the left atrial appendage orifice during systole have reduced magnitude. In the case of mitral regurgitation, a higher atrial pressure and disturbed flows are seen, especially during systole, when a large regurgitant jet can be found with the suppressed pulmonary venous flow. We also show that both the rule‐based and atlas‐based fibre defining methods lead to similar flow fields and atrial wall deformations. However, the changes in wall thickness from non‐uniform to uniform tend to underestimate the atrial deformation. Using a uniform but thickened wall also lowers the overall strain level. The flow velocity within the left atrial appendage, which is important in terms of appendage thrombosis, increases with the thickness of the left atrial wall. Energy analysis shows that the kinetic and dissipation energies of the flow within the left atrium are altered differently by atrial fibrillation and mitral valve regurgitation, providing a useful indication of the atrial performance in pathological situations.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Luo, Professor Xiaoyu and Griffith, Dr Boyce and Gao, Dr Hao and Feng, Mr Liuyang |
| Authors: | Feng, L., Gao, H., Griffith, B. E., Niderer, S. A., and Luo, X. |
| College/School: | College of Science and Engineering > School of Mathematics and Statistics |
| Journal Name: | International Journal for Numerical Methods in Biomedical Engineering |
| Publisher: | Wiley |
| ISSN: | 2040-7939 |
| ISSN (Online): | 2040-7947 |
| Published Online: | 27 August 2019 |
| Copyright Holders: | Copyright © 2019 The Authors |
| First Published: | First published in International Journal for Numerical Methods in Biomedical Engineering 35(11):e3254 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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