Isotopic labelling of quercetin 4 '-O-beta-D-glucoside

Caldwell, S. T. , Crozier, A. and Hartley, R. C. (2000) Isotopic labelling of quercetin 4 '-O-beta-D-glucoside. Tetrahedron, 56(24), pp. 4101-4106. (doi:10.1016/s0040-4020(00)00325-2)

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Abstract

[2-13C]-Quercetin-4′-O-β-glucoside was synthesised in four steps and 28% yield from barium [13C]-carbonate. This short route will be applicable to the synthesis of radiolabelled quercetin-4′-O-β-d-glucoside from barium [14C]-carbonate. The most important feature is control of the regiochemistry and stereochemistry of glycosylation before introduction of the isotopic label. The synthesis also uses only benzyl protecting groups allowing global deprotection in the last step.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Crozier, Professor Alan and Caldwell, Dr Stuart and Hartley, Professor Richard
Authors: Caldwell, S. T., Crozier, A., and Hartley, R. C.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
College of Science and Engineering > School of Chemistry
Journal Name:Tetrahedron
Publisher:Pergamon
ISSN:0040-4020
ISSN (Online):1464-5416
Published Online:05 June 2000

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