Stenvinkel, P. and Shiels, P. G. (2019) Long-lived animals with negligible senescence: clues for ageing research. Biochemical Society Transactions, 47(4), pp. 1157-1164. (doi: 10.1042/BST20190105) (PMID:31366472)
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Abstract
Among several theories to explain the complicated process of human ageing, the mitochondrial oxidative stress hypothesis has received recent attention. Considering that lifespan and ageing rates vary considerably across taxa, a better understanding of factors that lead to negligible or extremely rapid senescence in mammals may generate novel approaches to target human ageing. Several species, such as naked mole rats, ocean quahog, rockfish and Greenland shark, have been identified that exhibit negligible senescence and superior resistance to age-related diseases. Considering that the available literature suggests that their outstanding stress resistance is linked to maintenance of protein homeostasis and robust mitochondrial functions, treatments that target protein modification and upregulation of matrix antioxidants may have implications for extending human health span.
Item Type: | Articles |
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Additional Information: | The Heart and Lung Foundation supported Peter Stenvinkel’s research. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Shiels, Professor Paul |
Authors: | Stenvinkel, P., and Shiels, P. G. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Biochemical Society Transactions |
Publisher: | Portland Press |
ISSN: | 0300-5127 |
ISSN (Online): | 1470-8752 |
Published Online: | 31 July 2019 |
Copyright Holders: | Copyright © 2019 The Authors |
First Published: | First published in Biochemical Society Transactions 47(4):1157-1164 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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