Mackey, J. B.G., Coffelt, S. B. and Carlin, L. M. (2019) Neutrophil maturity in cancer. Frontiers in Immunology, 10, 1912. (doi: 10.3389/fimmu.2019.01912) (PMID:31474989) (PMCID:PMC6702268)
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Abstract
Neutrophils are implicated in almost every stage of oncogenesis and paradoxically display anti- and pro-tumor properties. Accumulating evidence indicates that neutrophils display diversity in their phenotype resulting from functional plasticity and/or changes to granulopoiesis. In cancer, neutrophils at a range of maturation stages can be identified in the blood and tissues (i.e., outside of their developmental niche). The functional capacity of neutrophils at different states of maturation is poorly understood resulting from challenges in their isolation, identification, and investigation. Thus, the impact of neutrophil maturity on cancer progression and therapy remains enigmatic. In this review, we discuss the identification, prevalence, and function of immature and mature neutrophils in cancer and the potential impact of this on tumor progression and cancer therapy.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Coffelt, Professor Seth and Mackey, John and Carlin, Dr Leo |
| Authors: | Mackey, J. B.G., Coffelt, S. B., and Carlin, L. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Research Centre: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology |
| Journal Name: | Frontiers in Immunology |
| Publisher: | Frontiers Media |
| ISSN: | 1664-3224 |
| ISSN (Online): | 1664-3224 |
| Copyright Holders: | Copyright © 2019 Mackey, Coffelt and Carlin |
| First Published: | First published in Frontiers in Immunology 10: 1912 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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