An arterial constitutive model accounting for collagen content and cross-linking

Holzapfel, G. A. and Ogden, R. W. (2020) An arterial constitutive model accounting for collagen content and cross-linking. Journal of the Mechanics and Physics of Solids, 136, 103682. (doi: 10.1016/j.jmps.2019.103682) (PMID:26654765) (PMCID:PMC4728033)

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It is apparent from the literature that the density of cross-links in collagenous tissue has a stiffening effect on the mechanical response of the tissue. This paper represents an initial attempt to characterize this effect on the elastic response, specifically in respect of arterial tissue. Two approaches are presented. First, a simple phenomenological continuum model with a cross-link-dependent stiffness is considered, and the influence of the cross-link density on the response in uniaxial tension is illustrated. In the second approach, a 3D model is developed that accounts for the relative orientation and stiffness of (two families of) collagen fibers and cross-links and their coupling using an invariant-based strain-energy function. This is also illustrated for uniaxial tension, and the influence of different cross-link arrangements and material parameters is detailed. Specialization of the model for plane strain is then used to show the effect of the cross-link orientation (relative to the fibers) and cross-link density on the shear stress versus the amount of shear deformation response. The elasticity tensor for the general (3D) case is provided with a view to subsequent finite element implementation.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Ogden, Professor Raymond and Holzapfel, Professor Gerhard
Authors: Holzapfel, G. A., and Ogden, R. W.
Subjects:Q Science > QA Mathematics
College/School:College of Science and Engineering > School of Mathematics and Statistics > Mathematics
Journal Name:Journal of the Mechanics and Physics of Solids
Journal Abbr.:JMPS
ISSN (Online):1873-4782
Published Online:09 August 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Journal of the Mechanics and Physics of Solids 136: 103682
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
694461EPSRC Centre for Multiscale soft tissue mechanics with application to heart & cancerRaymond OgdenEngineering and Physical Sciences Research Council (EPSRC)EP/N014642/1M&S - MATHEMATICS