Mechanisms and diagnostic evaluation of persistent or recurrent angina following percutaneous coronary revascularization

Crea, F., Bairey Merz, C. N., Beltrame, J. F., Berry, C. , Camici, P. G., Kaski, J. C., Ong, P., Pepine, C. J., Sechtem, U. and Shimokawa, H. (2019) Mechanisms and diagnostic evaluation of persistent or recurrent angina following percutaneous coronary revascularization. European Heart Journal, 40(29), pp. 2455-2462. (doi: 10.1093/eurheartj/ehy857) (PMID:30608528)

Abstract

Persistence or recurrence of angina after a percutaneous coronary intervention (PCI) may affect about 20–40% of patients during short–medium-term follow-up. This appears to be true even when PCI is ‘optimized’ using physiology-guided approaches and drug-eluting stents. Importantly, persistent or recurrent angina post-PCI is associated with a significant economic burden. Healthcare costs may be almost two-fold higher among patients with persistent or recurrent angina post-PCI vs. those who become symptom-free. However, practice guideline recommendations regarding the management of patients with angina post-PCI are unclear. Gaps in evidence into the mechanisms of post-PCI angina are relevant, and more research seems warranted. The purpose of this document is to review potential mechanisms for the persistence or recurrence of angina post-PCI, propose a practical diagnostic algorithm, and summarize current knowledge gaps.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Berry, Professor Colin
• Authors: Crea, F., Bairey Merz, C. N., Beltrame, J. F., Berry, C., Camici, P. G., Kaski, J. C., Ong, P., Pepine, C. J., Sechtem, U., and Shimokawa, H.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: European Heart Journal
• Publisher: Oxford University Press
• ISSN: 0195-668X
• ISSN (Online): 1522-9645
• Published Online: 04 January 2019
• Copyright Holders: Copyright © 2019 The Authors
• First Published: First published in European Heart Journal 40(29):2455-2462
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher