Grosset, K., Grosset, D. and Lees, A. (2005) Trial of subtherapeutic pergolide in de novo Parkinson's disease. Movement Disorders, 20(3), pp. 363-366. (doi: 10.1002/mds.20361) (PMID:15580607)
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Abstract
The effect of pergolide 25 μg twice daily on levodopa initiation was assessed in a randomized, placebo‐controlled, parallel group, double‐blind multicenter trial in 106 untreated early Parkinson's disease patients. The primary endpoint of mean time until levodopa was 520 days (95% confidence interval [CI], 422–618 days) for pergolide versus 434 days (95% CI, 358–609 days) for placebo. However, this increase of 86 days for pergolide was not statistically significant. The wash‐in effect of pergolide was significant at 6 weeks (change in mean Unified Parkinson's Disease Rating Scale [UPDRS] 2 and 3 was −0.1 [95% CI, −1.4 to 1.3] for pergolide vs. 2.2 [95% CI, 1.1–3.3] for placebo). At termination, the change from baseline in mean UPDRS 2 and 3 score was 11.4 (95% CI, 8.8–14) for pergolide and 14.6 (95% CI, 12–17.2) for placebo (P = 0.08). There was no significant change in UPDRS 2 and 3 for the 83 patients achieving the planned 4‐week washout at termination (pergolide 1.2 [95% CI, −0.8 to 3.2] vs. placebo 0.0 [95% CI, −1.6 to 1.6]. Adverse events were infrequent and occurred equally for pergolide and placebo. The study shows no evidence of a neuroprotective effect but indicates a mild symptomatic benefit from pergolide at a dose normally considered subtherapeutic.
Item Type: | Articles |
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Additional Information: | Lilly Pharmaceuticals supported the study through a grant to the United Kingdom Parkinson's Disease Research Group. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Grosset, Dr Katherine and Grosset, Professor Donald |
Authors: | Grosset, K., Grosset, D., and Lees, A. |
College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
Journal Name: | Movement Disorders |
Publisher: | Wiley |
ISSN: | 0885-3185 |
ISSN (Online): | 1531-8257 |
Published Online: | 03 December 2004 |
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