Successful Antiparkinsonian medication withdrawal in patients with Parkinsonism and normal FP-CIT SPECT

Marshall, V. L., Patterson, J., Hadley, D. M., Grosset, K. A. and Grosset, D. G. (2006) Successful Antiparkinsonian medication withdrawal in patients with Parkinsonism and normal FP-CIT SPECT. Movement Disorders, 21(12), pp. 2247-2250. (doi:10.1002/mds.21159) (PMID:17078059)

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Abstract

Between 4% and 14% of patients diagnosed with Parkinson's disease and entering clinical trials have normal presynaptic dopaminergic imaging. The effects of antiparkinsonian therapy have varied in these studies, and the consequences of stopping treatment are not reported. We present 11 patients who initially fulfilled diagnostic criteria and were treated for Parkinson's disease but in whom emerging diagnostic doubts led to antiparkinsonian therapy withdrawal, which was achieved without deterioration. Such cases represent a nondegenerative form of Parkinsonism, which does not benefit from dopaminergic therapy. Prospective vigilance regarding this category is of importance in clinical practice and clinical trials.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Grosset, Dr Donald and Hadley, Professor Donald and Patterson, Dr James and Marshall, Dr Vicky and Grosset, Dr Katherine
Authors: Marshall, V. L., Patterson, J., Hadley, D. M., Grosset, K. A., and Grosset, D. G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Movement Disorders
Publisher:Wiley
ISSN:0885-3185
ISSN (Online):1531-8257
Published Online:31 October 2006

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