Tracking Parkinson's: study design and baseline patient data

Malek, N. et al. (2015) Tracking Parkinson's: study design and baseline patient data. Journal of Parkinson's Disease, 5(4), pp. 947-959. (doi:10.3233/JPD-150662) (PMID:26485428) (PMCID:PMC4927877)

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Abstract

Background: There is wide variation in the phenotypic expression of Parkinson’s disease (PD), which is driven by both genetic and epidemiological influences. Objectives: To define and explain variation in the clinical phenotype of PD, in relation to genotypic variation. Methods: Tracking Parkinson’s is a multicentre prospective longitudinal epidemiologic and biomarker study of PD. Patients attending specialist clinics in the United Kingdom with recent onset (<3.5 years) and young onset (diagnosed <50 years of age) PD were enrolled. Motor, non-motor and quality of life assessments were performed using validated scales. Cases are followed up 6 monthly up to 4.5 years for recent onset PD, and up to 1 year for young onset PD. We present here baseline clinical data from this large and demographically representative cohort. Results: 2247 PD cases were recruited (1987 recent onset, 260 young onset). Recent onset cases had a mean (standard deviation, SD) age of 67.6 years (9.3) at study entry, 65.7% males, with disease duration 1.3 years (0.9), MDS-UPDRS 3 scores 22.9 (12.3), LEDD 295 mg/day (211) and PDQ-8 score 5.9 (4.8). Young onset cases were 53.5 years old (7.8) at study entry, 66.9% male, with disease duration 10.2 years (6.7), MDS-UPDRS 3 scores 27.4 (15.3), LEDD 926 mg/day (567) and PDQ-8 score 11.6 (6.1). Conclusions: We have established a large clinical PD cohort, consisting of young onset and recent onset cases, which is designed to evaluate variation in clinical expression, in relation to genetic influences, and which offers a platform for future imaging and biomarker research.

Item Type:Articles
Additional Information:on behalf of the PRoBaND clinical consortium.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Grosset, Dr Donald and Grosset, Dr Katherine
Authors: Malek, N., Swallow, D. M.A., Grosset, K. A., Lawton, M. A., Marrinan, S. L., Lehn, A. C., Bresner, C., Bajaje, N., Barker, R. A., Ben-Shlomo, Y., Burn, D. A., Foltynie, T., Hardy, J., Morris, H. R., Williams, N. M., Wood, N., and Grosset, D. G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Journal of Parkinson's Disease
Publisher:IOS Press
ISSN:1877-7171
ISSN (Online):1877-718X
Copyright Holders:Copyright © 2016 IOS Press and the Authors
First Published:First published in Journal of Parkinson's Disease 5(4): 947-959
Publisher Policy:Reproduced under a Creative Commons License
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