Overview of dopamine transporter imaging in Parkinson's disease, dementia with lewy bodies and other dementias

Malek, N. and Grosset, D. G. (2015) Overview of dopamine transporter imaging in Parkinson's disease, dementia with lewy bodies and other dementias. Current Geriatrics Reports, 4(2), pp. 124-130. (doi:10.1007/s13670-015-0126-9)

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Abstract

123I FP-CIT is a radiotracer that is used in conjunction with single photon emission computed tomography (SPECT) scanning to detect dopaminergic neuron pre-synaptic terminal degeneration, in the striatum (caudate nucleus and putamen) of patients with Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), showing a reduced uptake of this ligand by the dopamine transporters (DaT). This is a licensed diagnostic test in Europe (as DaTSCAN) and in the USA (as DaTscan). Recent work on functional imaging in PD and DLB largely uses the FP-CIT SPECT approach, and this is the focus of our paper, whilst noting that other ligands (e.g. beta-CIT) and imaging techniques such as positron emission tomography (PET) have been used in similar settings.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Grosset, Dr Donald
Authors: Malek, N., and Grosset, D. G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Current Geriatrics Reports
Publisher:Springer
ISSN:2196-7865
ISSN (Online):2196-7865
Published Online:01 April 2015
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