Gene discovery in Plasmodium chabaudi by genome survey sequencing

Janssen, C., Barrett, M. , Lawson, D., Quail, M., Harris, D., Bowman, S., Phillips, R. and Turner, C. (2001) Gene discovery in Plasmodium chabaudi by genome survey sequencing. Molecular and Biochemical Parasitology, 113(2), pp. 251-260. (doi: 10.1016/S0166-6851(01)00224-9)

Abstract

The first genome survey sequencing of the rodent malaria parasite Plasmodium chabaudi is presented here. In 766 sequences, 131 putative gene sequences have been identified by sequence similarity database searches. Further, 7 potential gene families, four of which have not previously been described, were discovered. These genes may be important in understanding the biology of malaria, as well as offering potential new drug targets. We have also identified a number of candidate minisatellite sequences that could be helpful in genetic studies. Genome survey sequencing in P. chabaudi is a productive strategy in further developing this in vivo model of malaria, in the context of the malaria genome projects.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Barrett, Professor Michael and Phillips, Professor Stephen and Turner, Professor Charles
• Authors: Janssen, C., Barrett, M., Lawson, D., Quail, M., Harris, D., Bowman, S., Phillips, R., and Turner, C.
• College/School: College of Medical Veterinary and Life Sciences; College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Molecular and Biochemical Parasitology
• Publisher: Elsevier BV
• ISSN: 0166-6851
• ISSN (Online): 1872-9428