Mitochondrial DNA: the overlooked oncogenome?

Gammage, P. A. and Frezza, C. (2019) Mitochondrial DNA: the overlooked oncogenome? BMC Biology, 17(1), 53. (doi: 10.1186/s12915-019-0668-y) (PMID:31286943) (PMCID:PMC6615100)

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Perturbed mitochondrial bioenergetics constitute a core pillar of cancer-associated metabolic dysfunction. While mitochondrial dysfunction in cancer may result from myriad biochemical causes, a historically neglected source is that of the mitochondrial genome. Recent large-scale sequencing efforts and clinical studies have highlighted the prevalence of mutations in mitochondrial DNA (mtDNA) in human tumours and their potential roles in cancer progression. In this review we discuss the biology of the mitochondrial genome, sources of mtDNA mutations, and experimental evidence of a role for mtDNA mutations in cancer. We also propose a 'metabolic licensing' model for mtDNA mutation-derived dysfunction in cancer initiation and progression.

Item Type:Articles
Additional Information:This work was supported by the Medical Research Council (MC_UU_00015/4 and MC_UU_12022/6).
Keywords:Cancer, metabolism, mitochondria, mtDNA.
Glasgow Author(s) Enlighten ID:Frezza, Mr Christian and Gammage, Dr Payam
Authors: Gammage, P. A., and Frezza, C.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:BMC Biology
Publisher:BioMed Central
ISSN (Online):1741-7007
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in BMC Biology 17(1):53
Publisher Policy:Reproduced under a Creative Commons License

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