Size-scaling effects for microparticles and cells manipulated by optoelectronic tweezers

Zhang, S., Li, W., Elsayed, M., Tian, P., Clark, A. W. , Wheeler, A. R. and Neale, S. L. (2019) Size-scaling effects for microparticles and cells manipulated by optoelectronic tweezers. Optics Letters, 44(17), pp. 4171-4174. (doi: 10.1364/OL.44.004171) (PMID:31465355)

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Abstract

In this work, we investigated the use of optoelectronic tweezers (OET) to manipulate objects that are larger than those commonly positioned with standard optical tweezers. We studied the forces that could be produced on differently sized polystyrene microbeads and MCF-7 breast cancer cells with light-induced dielectrophoresis (DEP). It was found that the DEP force imposed on the bead/cell did not increase linearly with the volume of the bead/cell, primarily because of the non-uniform distribution of the electric field above the OET bottom plate. Although this size-scaling work focuses on microparticles and cells, we propose that the physical mechanism elucidated in this research will be insightful for other micro-objects, biological samples, and micro-actuators undergoing OET manipulation.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Neale, Dr Steven and Zhang, Dr Shuailong and LI, WEIZHEN and Clark, Professor Alasdair
Authors: Zhang, S., Li, W., Elsayed, M., Tian, P., Clark, A. W., Wheeler, A. R., and Neale, S. L.
College/School:College of Science and Engineering > School of Engineering
College of Science and Engineering > School of Engineering > Biomedical Engineering
College of Science and Engineering > School of Engineering > Systems Power and Energy
Journal Name:Optics Letters
Publisher:Optical Society of America
ISSN:0146-9592
ISSN (Online):1539-4794
Published Online:22 July 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Optics Letters 44(17):4171-4174
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
652331Assembly of electronic components with Optoelectronic TweezersSteven NealeEngineering and Physical Sciences Research Council (EPSRC)EP/L022257/1ENG - BIOMEDICAL ENGINEERING