New perspectives and future directions in the treatment of heart failure

Pellicori, P. , Khan, M. J. I., Graham, F. J. and Cleland, J. G.F. (2020) New perspectives and future directions in the treatment of heart failure. Heart Failure Reviews, 25, pp. 147-159. (doi: 10.1007/s10741-019-09829-7) (PMID:31327116) (PMCID:PMC6985084)

Abstract

The management of heart failure has changed significantly over the last 30 years, leading to improvements in the quality of life and outcomes, at least for patients with a substantially reduced left ventricular ejection fraction (HFrEF). This has been made possible by the identification of various pathways leading to the development and progression of heart failure, which have been successfully targeted with effective therapies. Meanwhile, many other potential targets of treatment have been identified, and the list is constantly expanding. In this review, we summarise planned and ongoing trials exploring the potential benefit, or harm, of old and new pharmacological interventions that might offer further improvements in treatment for those with HFrEF and extend success to the treatment of patients with heart failure with preserved left ventricular ejection fraction (HFpEF) and other heart failure phenotypes.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Graham, Dr Fraser and Cleland, Professor John and Khan, Dr Muhammad and Pellicori, Dr Pierpaolo
• Authors: Pellicori, P., Khan, M. J. I., Graham, F. J., and Cleland, J. G.F.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre
• Journal Name: Heart Failure Reviews
• Publisher: Springer
• ISSN: 1382-4147
• ISSN (Online): 1573-7322
• Published Online: 20 July 2019
• Copyright Holders: Copyright © 2019 The Authors
• First Published: First published in Heart Failure Reviews 25:147–159
• Publisher Policy: Reproduced under a Creative Commons License