Parvy, J.-P., Yu, Y., Dostalova, A., Kondo, S., Kurjan, A., Bulet, P., Lemaitre, B., Vidal, M. and Cordero, J. B. (2019) The antimicrobial peptide Defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila. eLife, 8, e45061. (doi: 10.7554/eLife.45061) (PMID:31358113) (PMCID:PMC6667213)
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Abstract
Antimicrobial peptides (AMPs) are small cationic molecules best known as mediators of the innate defence against microbial infection. While in vitro and ex vivo evidence suggest AMPs’ capacity to kill cancer cells, in vivo demonstration of an anti-tumour role of endogenous AMPs is lacking. Using a Drosophila model of tumourigenesis, we demonstrate a role for the AMP Defensin in the control of tumour progression. Our results reveal that Tumour Necrosis Factor mediates exposure of phosphatidylserine (PS), which makes tumour cells selectively sensitive to the action of Defensin remotely secreted from tracheal and fat tissues. Defensin binds tumour cells in PS-enriched areas, provoking cell death and tumour regression. Altogether, our results provide the first in vivo demonstration for a role of an endogenous AMP as an anti-cancer agent, as well as a mechanism that explains tumour cell sensitivity to the action of AMPs.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Cordero, Professor Julia and Yu, Dr Yachuan and Vidal, Dr Marcos and Parvy, Dr Jean-Philippe |
Creator Roles: | Cordero, J.Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review and editing Vidal, M.Conceptualization Parvy, J.-P.Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review and editing Yu, Y.Formal analysis, Investigation |
Authors: | Parvy, J.-P., Yu, Y., Dostalova, A., Kondo, S., Kurjan, A., Bulet, P., Lemaitre, B., Vidal, M., and Cordero, J. B. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | eLife |
Publisher: | eLife Sciences Publications |
ISSN: | 2050-084X |
ISSN (Online): | 2050-084X |
Published Online: | 30 July 2019 |
Copyright Holders: | Copyright © 2019 Parvy et al. |
First Published: | First published in ELife 8:e45061 |
Publisher Policy: | Reproduced under a Creative Commons license |
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