Altuncu, S., Demir Duman, F. , Gulyuz, U., Yagci Acar, H., Okay, O. and Avci, D. (2019) Structure-property relationships of novel phosphonate-functionalized networks and gels of poly(β-amino esters). European Polymer Journal, 113, pp. 155-164. (doi: 10.1016/j.eurpolymj.2019.01.052)
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Abstract
pH sensitivity, biodegradability and high biocompatibility make poly(β-amino esters) (PBAEs) important biomaterials with many potential applications including drug and gene delivery and tissue engineering, where their degradation should be tuned to match tissue regeneration rates. Therefore, we synthesize novel phosphonate-functionalized PBAE macromers, and copolymerize them with polyethylene glycol diacrylate (PEGDA) to produce PBAE networks and gels. Degradation and mechanical properties of gels can be tuned by the chemical structure of phosphonate-functionalized macromer precursors. By changing the structure of the PBAE macromers, gels with tunable degradations of 5–97% in 2 days are obtained. Swelling of gels before/after degradation is studied, correlating with the PBAE identity. Uniaxial compression tests reveal that the extent of decrease of the gel cross-link density during degradation is much pronounced with increasing amount and hydrophilicity of the PBAE macromers. Degradation products of the gels have no significant cytotoxicity on NIH 3T3 mouse embryonic fibroblast cells.
| Item Type: | Articles |
|---|---|
| Additional Information: | The authors thank TUBITAK (114Z926) for financial support. O.O. thanks the Turkish Academy of Sciences (TUBA) for the partial support. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Demir Duman, Dr Fatma |
| Authors: | Altuncu, S., Demir Duman, F., Gulyuz, U., Yagci Acar, H., Okay, O., and Avci, D. |
| Subjects: | Q Science > QD Chemistry |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | European Polymer Journal |
| Publisher: | Elsevier |
| ISSN: | 0014-3057 |
| ISSN (Online): | 1873-1945 |
| Published Online: | 24 January 2019 |
| Copyright Holders: | Copyright © 2019 Elsevier |
| First Published: | First published in European Polymer Journal 113:155-164 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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