Pure hydrophilic block copolymer vesicles with redox- and pH-cleavable crosslinks

Willersinn, J. and Schmidt, B. V.K.J. (2018) Pure hydrophilic block copolymer vesicles with redox- and pH-cleavable crosslinks. Polymer Chemistry, 9(13), pp. 1626-1637. (doi: 10.1039/C7PY01214D)

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The self-assembly of a novel double hydrophilic block copolymer consisting of biocompatible blocks, namely pullulan-b-poly(N-vinylpyrrolidone), is presented. Completely hydrophilic spherical structures with an average apparent radius of 800 nm at increased concentrations in water are observed via dynamic light scattering as well as cryo scanning electron microscopy and confocal laser scanning microscopy techniques. Moreover, the pullulan block is converted to present aldehyde groups acting as anchor point for crosslinker attachments. It is demonstrated, that the oxidized self-assembled particles could be crosslinked via the bifunctional crosslinker cystamine forming dynamic covalent imine linkages with aldehyde groups. The afforded vesicles with an average diameter of 700 nm are stable upon high dilution and could be observed via cryo scanning electron microscopy and transmission electron microscopy. Furthermore, it is possible to cleave the crosslinking bonds with the treatment of acid or the application of a reducing agent. The responsivity is a key feature taking future applications in the biomedical sector into account.

Item Type:Articles
Additional Information:Open Access funding provided by the Max Planck Society.
Glasgow Author(s) Enlighten ID:Schmidt, Dr Bernhard
Authors: Willersinn, J., and Schmidt, B. V.K.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Polymer Chemistry
Publisher:Royal Society of Chemistry
ISSN (Online):1759-9962
Published Online:22 August 2017
Copyright Holders:Copyright © 2018 The Royal Society of Chemistry
First Published:First published in Polymer Chemistry 9(13): 1626-1637
Publisher Policy:Reproduced under a Creative Commons License

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