Short, B., Brown, J. , Delaney, C., Sherry, L. , Williams, C., Ramage, G. and Kean, R. (2019) Candida auris exhibits resilient biofilm characteristics in vitro: implications for environmental persistence. Journal of Hospital Infection, 103(1), pp. 92-96. 31226270. (doi: 10.1016/j.jhin.2019.06.006)
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Abstract
Surfaces within healthcare play a key role in the transmission of drug-resistant pathogens. Candida auris is an emerging multi-drug resistant yeast which has the ability to survive for prolonged periods on environmental surfaces. Here we show that the ability to form cellular aggregates increases survival after 14 days, which coincides with the upregulation of biofilm-associated genes. Additionally, the aggregating strain demonstrated tolerance to clinical concentrations of sodium hypochlorite and remain viable 14 days’ post treatment. The ability of C. auris to adhere and persist on environmental surfaces emphasises our need to better understand the biology of this fungal pathogen.
Item Type: | Articles |
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Additional Information: | This study has been funded by a research grant in 2017 by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) to L.S. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Kean, Mr Ryan and Brown, Dr Jason and Delaney, Mr Christopher and Ramage, Professor Gordon and Williams, Dr Craig and Sherry, Dr Leighann |
Authors: | Short, B., Brown, J., Delaney, C., Sherry, L., Williams, C., Ramage, G., and Kean, R. |
College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School |
Journal Name: | Journal of Hospital Infection |
Publisher: | Elsevier |
ISSN: | 0195-6701 |
ISSN (Online): | 1532-2939 |
Published Online: | 18 June 2019 |
Copyright Holders: | Copyright © 2019 The Healthcare Infection Society |
First Published: | First published in Journal of Hospital Infection 103(1):92-96 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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