Imaging tumor metabolism using positron emission tomography

Lewis, D. Y. , Soloviev, D. and Brindle, K. M. (2015) Imaging tumor metabolism using positron emission tomography. Cancer Journal, 21(2), pp. 129-136. (doi: 10.1097/PPO.0000000000000105) (PMID:25815854) (PMCID:PMC4413031)

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Positron emission tomography (PET) is an extraordinarily sensitive clinical imaging modality for interrogating tumor metabolism. Radiolabeled PET substrates can be traced at subphysiological concentrations, allowing noninvasive imaging of metabolism and intratumoral heterogeneity in systems ranging from advanced cancer models to patients in the clinic. There are a wide range of novel and more established PET radiotracers, which can be used to investigate various aspects of the tumor, including carbohydrate, amino acid, and fatty acid metabolism. In this review, we briefly discuss the more established metabolic tracers and describe recent work on the development of new tracers. Some of the unanswered questions in tumor metabolism are considered alongside new technical developments, such as combined PET/magnetic resonance imaging scanners, which could provide new imaging solutions to some of the outstanding diagnostic challenges facing modern cancer medicine.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Lewis, Dr David
Authors: Lewis, D. Y., Soloviev, D., and Brindle, K. M.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Cancer Journal
Publisher:Lippincott Williams & Wilkins
ISSN (Online):1540-336X

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