Fassan, M. et al. (2019) miR-224 is significantly upregulated and targets caspase-3 and caspase-7 during colorectal carcinogenesis. Translational Oncology, 12(2), pp. 282-291. (doi: 10.1016/j.tranon.2018.10.013) (PMID:30448733) (PMCID:PMC6240712)
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Abstract
miR-224 has recently emerged as a driver oncomiR in sporadic colorectal carcinogenesis, but its pathogenetic role is still controversial. A large phenotypical and molecularly characterized series of preinvasive and invasive colorectal lesions was investigated for miR-224 expression by qRT-PCR and in situ hybridization. The caspase-3 and caspase-7 status was also assessed and correlated to miR-224 dysregulation. miR-224 was significantly upregulated during the adenoma-carcinoma sequence and in the context of inflammatory bowel disease dysplastic lesions, whereas its expression was significantly downregulated among BRAF-mutated tumors and in the presence of a DNA mismatch repair deficiency. miR-224 targets caspase-3 and caspase-7 in colorectal cancer, and this inverse relation was already evident from the earliest phases of transformation in intestinal mucosa. The miR-224/caspases axis may represent an interesting field of study for innovative biomarkers/therapeutics for BRAF-mutated/DNA mismatch repair-deficient tumors.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Braconi, Professor Chiara and Valeri, Dr Nicola |
| Authors: | Fassan, M., Cui, R., Gasparini, P., Mescoli, C., Guzzardo, V., Vicentini, C., Munari, G., Loupakis, F., Lonardi, S., Braconi, C., Scarpa, M., D'Angelo, E., Pucciarelli, S., Angriman, I., Agostini, M., D'Incá, R., Farinati, F., Gafà, R., Lanza, G., Frankel, W. L., Croce, C. M., Valeri, N., and Rugge, M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Translational Oncology |
| Publisher: | Elsevier |
| ISSN: | 1944-7124 |
| ISSN (Online): | 1936-5233 |
| Published Online: | 16 November 2018 |
| Copyright Holders: | Copyright © 2018 The Authors |
| First Published: | First published in Translational Oncology 12(2): 282-291 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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